Unique sequence of pernicious anemia, polycythemia, and acute leukemia.

Polycythemia rubra vera with pernicious anemia. Some observations on vitamin B 12 metabolism.

By ROBERT E. SAGE P ERSISTENT rather than relative and transient polycythemia was first described in 1892 by Vaquez.’ Polycythemia rubra vera is now regarded as one of the myeloproliferative disorders. A slowly progressive neoplasm of unknown etiology involving all cell series of the bone marrow, it is inevitably fatal after a varying period of time.24 The first clinical description of pernicio...

Pernicious anemia, megaloblastosis and the di Guglielmo syndrome.

Erythrocyte Vitamin B12 Activity in Health, Polycythemia, and in Deficiency of Vitamin B12 and Folate

T HERE HAS BEEN RELATIVELY LITTLE WORK on the estimation of erythrocyte vitamin B12 activity in man, and consequently there are few reports of its activity in disease states. Sobotka et al.1 reported low levels in four cases of pernicious anemia ( P. A. ) , using E. gracilis and 0. maihamensis. This was confirmed by Biggs et al.,2 who also reported the levels found in treated cases of polycythe...

Variations of Human Blood Cell Zinc in Disease.

Variations in the amount of zinc in human blood cells have been correlated with several diseases and morphological features. In 1949, Vallee and Gibson observed that in pernicious anemia erythrocyte zinc is elevated to a degree even exceeding what might be related to macrocytosis (1). A correlation of carbonic anhydrase activity with erythrocyte zinc content was demonstrated (2, 3). Subsequent ...

Radioactive Iron Absorption in Clinical Conditions: Normal, Pregnancy, Anemia, and Hemochromatosis

Radio iron is a tool which makes iron absorption studies quite accurate in dogs and reasonably satisfactory in human beings. This method is vastly superior to others previously used. Normal human pregnancy without significant anemia may show active radio iron absorption-16 to 27 per cent of iron intake. The pregnant woman as a rule shows 2 to 10 times the normal absorption of radio iron. Diseas...